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Memory encoding in the brain

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Recollecting memories is a straightforward task for humans – a modest act of closing our eyes frequently conveys a flood of flashes rushing back. 

However, underneath this apparently effortless experience, there exist complex neural procedures.

Dartmouth College scientists have recognized the complex neurological systems that control how the human brain stores memories. 

The results revealed a “neural coding mechanism” in the brain that permits information to be transported between perception and memory regions. 

We found that memory-related brain areas translate the world like a ‘photographic negative’ in space,” said Adam Steel, the co-lead author, in an authorized release. 

And that ‘negative’ is the portion of the process that move data in and out of memory, and between perceptual and memory systems, added Steel, who is a postdoctoral investigator in the Division of Psychological and Brain Sciences and associate at the Neukom Institute for Computational Science at Dartmouth

The scientists commenced a sequence of tests to study more about how the brain encrypts and recollect detailed memories. 

The team used functional magnetic resonance imaging (fMRI) to seizure brain activity in study applicants evaluated on perception and memory. 

By means of these experiments, the team identified a “push-pull coding mechanism” that controls the interface between perceptual and memory areas.

The outcomes indicated that when light hits the retina, visual zones of the brain answer by increasing their activity to characterize the pattern of light. Memory parts of the brain also respond to visual stimulation, but, unlike visual areas, their neural actions decline when processing the identical visual pattern, described the release. 

The researchers were able to isolate three key conclusions from their extensive observations. 

Initially, scientists discovered that brain memory structures retain a visual coding basis. Secondly, this visual code is presented “upside-down” in memory systems, signifying a distinct brain processing property. 

When you notice something in your visual field, neurons in the visual cortex are driving whereas those in the memory system are silenced, said senior author Caroline Robertson, an associate professor of psychological and brain sciences at Dartmouth.

Finally, the relation between perceptual and memory systems flips during memory recollection, underlining the intricate dynamics at work.

If you close your eyes and recollect that visual stimulus in the same space, you’ll flip the connection: your memory system will be driving, overwhelming the neurons in perceptual regions, added Robertson, in the press release.

The following step for the study team is to look at how this push-pull dynamic between perception and memory might assist us understand cognitive processes in sicknesses like Alzheimer’s.

The discovery opens up new pathways for studying the complex interaction between awareness and memory, possibly leading to developments in neuroscience and therapeutic study.

The conclusions were published in the journal Nature Neuroscience.

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