Skewed blood cells may have impact on cancer rates


Related stories

World water day

Global (Commonwealth Union) - World Water Day is an...

  Study shows new method of clearing toxins associated to Alzheimer’s disease

Science & Technology, Singapore (Commonwealth Union) - Alzheimer's disease...

Increased caffeine may lower weight and type 2 diabetes risk

Science & Technology, UK (Commonwealth Union) - Caffeine is...

Newfangled semiconductors for 5G and 6G in India

(Commonwealth) _ Polymatech Electronics, a leading semiconductor chip manufacturer,...

Preterm babies not accustomed to repetition in pain

Science & Technology, UK (Commonwealth Union) - Preterm babies,...

England (Commonwealth Union) – Researchers have found that people who have a ‘skewed’ pattern in their immune blood cells have twice the possibility to develop cancer later in life.

A study led by King’s College London has given new insights on the way skewed X chromosome inactivation (XCI-skew) is linked to developing chronic disease. Basic genetics show us that in human males have the XY chromosomes and females have XX chromosomes, in every cell that has two X chromosomes generally in females 1 of the 2 is silenced, which is referred to as X chromosome inactivation (XCI). This occurs early in development and is fixed for every cell, making sure each body cell has 1 functional copy of the X chromosome.

The X that is silenced is chosen at random and so it is expected that each X will be silenced in half the cells. However, as we grow older and form new immune blood cells, some form a pattern of XCI, quite different to the expected 50:50 ratio, known as XCI-skew and it is unknown presently as to why this happens in certain people.

Scientists evaluated the health information of 1,575 females from TwinsUK, which is the biggest adult twin registry in the UK, having the most clinical details across the globe, discovering that individuals with this skewed pattern in their blood cells are twice as likely to get cancer in a 10-year period, and they score more for risk factors of getting cardiovascular disease as well. Additionally, they carried out a prospective 10-year follow-up study discovering that even slight XCI-skew showed a higher probability of future cancer diagnosis, in all types of cancer.

“From our results, we hypothesise that XCI-skew in blood tissue does not directly cause cancer later in life. Rather, XCI-skew is likely to be a marker of chronic inflammation, which can stimulate tumour growth,” said the lead author Dr Amy Roberts, Postdoctoral Research Fellow at the Department of Twin Research and Genetic Epidemiology.


Stay up to date with the latest news from the Commonwealth Union

Latest stories

Electronic Genset launched by Su-vastika in India

(Commonwealth) _ Su-vastika, a leading manufacturer of power solutions,...

Killing cancer cells with bacteria

Science & Technology, Australia (Commonwealth Union) – A new...

Citizen scientist’s role for native plants

Science & Technology, Australia (Commonwealth Union) – A new...

After months of trepidation, Sri Lanka gets the much-awaited IMF Bailout

Colombo Sri Lanka (Commonwealth Union)_The much-awaited and anticipated bailout...

Official Sri Lanka Launch of the Commonwealth Union Media Portal .

The official Sri Lankan launch of the Commonwealth Union...


Please enter your comment!
Please enter your name here