Europe UK (Commonwealth Union) – The University of Cambridge has set out a project forming the 1st governance framework for studies working on stem cell-based human embryo models within the UK.
The Governance of Stem Cell-Based Embryo Models (G-SCBEM) project will have Cambridge Reproduction at its lead seeing the collaboration of researchers, legal scholars, and bioethics experts, together with representatives from prominent funders as well as regulators of this research.
Stem cell-derived embryo models (SCDEMs) are 3D constructs designed to replicate certain aspects of embryo development. These models are generated using embryonic stem cells that can be induced to form structures resembling the embryonic blastocyst stage. This stage marks the beginning of the implantation process in natural conception, and SCDEMs aim to emulate its key features.
At present, there is a lack of specific regulations that tackles the use of SCBEMs in research. However, it is important to note that current UK legislation prohibits the transfer of SCBEMs into a woman’s uterus. Nevertheless, the absence of transparent and well-defined guidance in this field hampers research progress and poses a risk of undermining public confidence.
To address this issue, Cambridge Reproduction, in collaboration with the Progress Educational Trust (PET), is actively working towards breaking this impasse. Their objective is to develop a comprehensive and unambiguous recommended governance framework for conducting research involving SCBEMs. Recognizing that this is an emerging field of study, the team is actively seeking input from a wide range of stakeholders to identify the opportunities, areas of consensus, and concerns surrounding the use of SCBEMs.
The consultation will set up the groundwork for working with the public along with other stakeholders in a parallel two-way dialogue in regard to the application of SCBEMs for research and translation as well.
“This is a fast-developing area and the project will open important dialogues with researchers, funders, regulators, and the general public,” explained Professor Kathy Niakan, who is Chair of Cambridge Reproduction. “We hope that the resulting self-governance framework will enable scientists to proceed with their research with confidence while maintaining public trust in this vital area of research.”
